Medications for Erectile Dysfunction

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Few Drugs Used for Erectile Dysfunction Treatment are Listed Below:

Generic Name and Action	Brand Name(s)	Common Dosages	Side Effects	Special Considerations	Comments
Sildenafil -- increases blood flow	Viagra® (Pfizer) 800-533-4535	Starting dose is 50 mg orally approx. 1 hour before sexual intercourse. Depending on side effects or response, a physician may decrease dose to 25 mg or may gradually increase the dose to a maximum dose of 100 mg.	Headache, flushing, heartburn, changes in vision, dizziness, and diarrhea	The use of Viagra is contraindicated in pts. currently taking any form of nitroglycerin such as: patches, tablets, sublingual. Pts. with cardiac risk factors such as hypertension, obesity or cigarette smoking should use with extreme caution.	Currently approved for impotence in males only. Do not take more than the prescribed dose by a physician. Contact a physician immediately if an erection lasts longer than 4 hours.
Alprostadil (penile suppository) ---- increases blood flow	Muse® (Vivus) 800-615-2416	Starting dose is 125-250 mcg. Insert suppository into the urethra approx. 15 min before sexual intercourse. Depending on side effects and response, a physician may slowly increase dose to a maximum of 1000 mcg. Do not use more than 2 doses within a 24 hour period.	Flushing, nausea, abdominal cramps, increase heart rate, decrease in blood pressure, dizziness, not feeling well and/or fluid retention	Store under refrigeration. Take out of the refrigerator, 30 minutes prior to use.	Sit, stand, or walk for about 10 minutes after insertion of the suppository. Contact a physician immediately if an erection lasts longer than 4 hours.
Alprostadil (penile injection) --increases blood flow	Caverject® (Pharmacia & Upjohn) 800-253-8600	Starting dose is 2.5 mcg given by injection in the shaft of the penis. Depending on side effects and response, a physician may decrease or increase the dose. The recommended frequency of injection is 3 times a week, with at least 24 hours between injections.	Flushing, nausea, abdominal cramps, increase heart rate, decrease in blood pressure, dizziness, not feeling well, and/or fluid retention	Store at room temperature, use the solution immediately upon reconstitution.	First time dose must take place while a physician is present, to ensure proper dose and technique. Contact a physician immediately if an erection lasts longer than 4 hours. Do not use in rectum.
Yohimbine -- increases blood flow	Yocon® (Glenwood) 201-569-0050	5 mg three times daily by mouth.	Increase in blood pressure and heart rate, irritability, tremor, headache, flushing, and dizziness	Discontinue after 10 weeks if therapy produces no positive response. Usual response time is 3 days to 3 weeks.	Studies have shown that it may be effective in treating patients who have psychological rather than neurological symptoms. Contact a physician immediately if an erection lasts longer than 4 hours.
Papaverine -- increases blood flow	(Schein Pharmaceuticals) 973-593-5500	Starting dose is 20-30 mg injected in the shaft of the penis. Depending on side effects and response, a physician may decrease or increase the dose.	Drowsiness, dizziness, headache, nausea, vomiting, weight loss, diarrhea, liver disease, and skin rash	This medication has the potential for more serious adverse effects than other male impotence medications. Side effects need to be closely monitored by physician	First time dose must take place while a physician is present, to ensure proper dose and technique. Contact a physician immediately if an erection lasts longer than 4 hours. Papaverine can also be used in combination with phentolamine.

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