Hormonal Therapy May Reduce the Risk of Colo-Rectal Cancer

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Recent studies show that hormonal replacement therapy, which was abandoned by the women in the age finding that could lead to breast cancer, reduces substantially the risk of a colo-rectal cancer.

The most remarkable reduction in the risk-48 percent-was observed in women who received hormonal therapy with combined estrogen and progestin for a period of 2 to 5 years, researchers reported in the latest edition of Cancer Epidemiology, Biomarkers and Prevention, published by the American Association for Cancer Research.

"Despite the decline in use last period of all hormonal preparations during menopause, these results suggest an important protective effect that would have these hormonal preparations, especially the combination of estrogen with progestin for the large number of women in menopause who require Hormonal replacement therapy, "noted Dr. Jill R. Johnson of the University of Minnesota, Minneapolis with his colleagues there and at the National Cancer Institute in Bethesda, Maryland.

Findings arise because in analyzing the evolution of the 56.733 women pursued over a period average of 15 years, of which 960 were diagnosed with colorectal cancer rectal. Average women who participated in the first interview carried out between 1979-1981 was held 55 , 7 years.

Any use of estrogen therapy has a risk associated with lower 17% of developing colo-rectal cancer in individuals receiving, cercetatorii. Dintre found women treated with estrogen, the most pronounced decrease was recorded among those who used this treatment are currently (25 percent) and those who have used this therapy for a period of 10 or more years (with an 26 percent lower).

Johnson and colleagues have found a decreased risk by 22 percent of developing colo-rectal cancer and those who have used at least once combined therapy of estrogen with progestin. People who have used this treatment in the past but dropped the combined result of at least 5 years, have recorded a decreased risk by 45 percent.

Although the current study was not designed to determine the biological mechanisms involved in the induction of this apparent protective effect, previous studies have shown that hormones play a role in decreasing insulin growth factor-like explaining the lower risk of colo-rectal cancer. "Biological mechanism will be explored in subsequent studies," he told Johnson.

Present findings differ from those reported by Women's Health Initiative, researchers have noted, who claimed that estrogen therapy does not exert any effect on the risk of colo-rectal cancer. They explain this result by nul shortest duration of treatment before and ages of patients examined in that study.

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