Glucosamine and Chondroitin Sulfate

Glucosamine for osteoarthritis

Composition

Tablet:

Each film coated tablet contains Glucosamine Sulfate 250 mg as Glucosamine Sulfate Potassium Chloride USP & Chondroitin Sulfate 200 mg as Chondroitin Sulfate Sodium USP.

Pharmacology

Glucosamine (2-amino-2-deoxy-alpha-D-glucose) is a natural amino-sugar, produced by the body and found in certain foods. It is the most fundamental building block required for biosynthesis of glycosaminoglycans (GAGs) like Hyaluronic Acid, Keratan Sulfate, and Chondroitin Sulfate. GAGs binds with protein and form proteoglycans, the essential building block of articular cartilage. When cartilage in a joint deteriorates, Osteoarthritis develops. It also helps to form ligaments, tendon, nails, and various other connective tissues. When we take artificially synthesised Glucosamine Sulfate supplement, it increases Glucosamine level in the body, thus facilitates production and repair of cartilage. Glucosamine also activates chondrocytes in the cartilage which helps to pro-duce GAGs and proteoglycans. Chondroitin Sulfate is a glycosaminoglycan (acid muco-polysaccharide) found in connective tissue, especially in the articular cartilage of all mammals. Chondroitin Sulfate supplement acts similarly as Glucosamine Sulfate, since it also provide substrate for proteoglycans.

Chondroitin also protects existing healthy cartilage from premature decline by preventing the MMP (Matrix metal loproteinase) enzyme that breakdowns the proteoglycans. Combining Glucosamine with Chondroitin Sulfate shows synergistic effect. Data supports that this combination has been shown to be very much effective in severe cases of Osteoarthritis that treats both sign and symptoms of osteoarthritis and modifies disease progression. It prevents osteoarthritis in case of normal adults. In osteoarthritic pain it is as effective as NSAIDs with significantly better tolerability and clinical compliance. It is also helpful during the repair phase of musculo-skeletal soft tissue injuries such as tendon or ligament strains.

Indication

Treatment of osteoarthritis of fingers, shoulder joints and weight bearing joints of the body. As a dietary supplement to prevent osteoarthritis.

Dosage and Administration

1 - 2 tablets, three times daily. Dose may be adjusted according to the response of the drug and body weight. Doses can be tapered after 60 days as per requirement of the individual and for cost convenience. Typical dosage recommendation, based on body weight is as follows- Under 54 Kg: 800 mg Chondroitin Sulfate and 1000 mg Glucosamine Sulfate per day, 54 Kg- 91 Kg: 1200 mg Chondroitin Sulfate and 1500 mg Glucosamine Sulfate per day, Over 91 Kg: 1600 mg Chondroitin Sulfate and 2000 mg Glucosamine Sulfate per day

Contraindication

There is no known contraindication to Glucosamine or Chondroitin. But proven hypersensitivity to these ingredients is a contraindication.

Precaution

Patients with Diabetes Mellitus are advised to monitor blood glucose levels regularly when taking Glucosamine. No special studies were formed in patients with renal or hepatic insufficiency. The toxicological and pharmacokinetic profile of Glucosamine and Chondroitin does not indicate limitations for these patients. However, administration to patients with severe hepatic or renal insufficiency should be under appropriate medical supervision. Children should not be supplemented with Glucosamine and Chondroitin.

Side Effect

Safety studies with Glucosamine Sulfate and Chondroitin Sulfate show no demonstrable side effects. Rarely occurring side effects (such as, mild and reversible intestinal flatulence) are almost like placebo.

Use in Pregnancy and Lactation

Women who are pregnant should not supplement with Glucosamine Sulfate or Chondroitin Sulfate. Glucosamine and Chondroitin has not been studied enough to determine their effects on a developing fetus. No studies have evaluated the use of Glucosamine and Chondroitin during pregnancy or lactation. It should be taken with caution and medical advice during pregnancy and lactation.

Drug Interaction

There have been no reports of significant drug interactions of Glucosamine and Chondroitin with Antibiotics/ Antidepressants/ Anti hypertensives/ Nitrates/ Antiarrythmics/ Anxiolytic/ Hypoglycemic agents/ Antisecretives / Antiasthmatics. Chondroitin may enhance the blood thinning effects of anticoagulants like Warferine, Heparine.

Pharmaceutical Precaution

Tablet:

Box containing tablets in Alu-Alu blister pack.

Similar of Glucosamine and Chondroitin Sulfate

Bones and Joints Related Q & A

Bones and Joints Related Q & A How Glucosamine And Chondroitin Help Joint Pain? Are These Supplements Approved By Fda As Prescription Drugs? Glucosamine and chondroitin are normal

Disorders of Joints and Connective Tissue

Disorders of Joints and Connective Tissue Disorders that affect joints and their compo-nents-muscles, bones, cartilage, and tendons- -are considered connective tissue diseases because these structures

Kidney Care - Kidney & Bladder Support Formula

Viable Herbal Solutions understands today's issues regarding better health and well-being, and we offer you the benefit of our personal, technical &

The Aging Body

The average life expectancy has increased dramatically in the United States. A male child born in 1900 could expect to live only 46 years, whereas one born

Protein That Regulates Aging May Provide Key To New Diabetes Therapies

Opening the possibility of new therapies for type 2 diabetes, researchers at Washington University School of Medicine in St. Louis have found that a protein

Asthma in Pregnancy

The natural history of asthma in pregnancy is extremely variable. Pregnancy can affect the course of asthma & asthma can affect pregnancy outcomes. Severe

Evolution of Drug Coated Coronary Stents : A Major Breakthrough in Managing Coronary Artery Disease

Coronary Artery Stenosis is a common Cardiac problem leading to heart attack. Instead of Coronary Bypass Surgery, Balloon Angioplasty has become a popular

Topics:

Comments

Post new comment