Effectiveness of 64 Slice Computed Tomography in Cardiac Care Validated

September 26-2005 Monday

Clinical Studies Demonstrate Effectiveness of Siemens 64-Slice Computed Tomography in Cardiac Care. More Than 350 Somatom Sensation 64 Systems Installed Worldwide

Engaging in intensive research during the past twelve months, Siemens' clinical collaborators continue to lead the scientific community in studies focusing on the clinical validation of multi-slice CT systems in cardiac imaging. Siemens Medical Solutions Somatom® Sensation 64 computed tomography (CT) system is the most successful 64-slice CT system with more than 350 installations worldwide. Over 40 percent of these installations include the Somatom Sensation Cardiac 64, which specializes in the diagnosis and treatment of cardiovascular disease.

In the published studies, results derived from 64-slice CT were compared to traditional invasive catheter angiography and intravascular ultrasound (IVUS). The authors of all the articles highlight the Somatom Sensation 64's excellent image quality with an isotropic spatial resolution of below 0.4 millimeter in all routine and cardiac scan modes, enabling a new level of clinical confidence. Using z-Sharp™ Technology and a rotation speed of 0.33 seconds, the system supplies high quantitative and qualitative diagnostic accuracy for the non-invasive assessment of coronary artery stenoses, coronary plaque composition and plaque burden in a broad spectrum of patients.

A study conducted by Leschka et al. from the University Hospital, Zurich, Switzerland investigated the accuracy of the Somatom Sensation 64 for assessing hemodynamically significant stenoses of coronary arteries in a consecutive patient population. The Somatom Sensation 64's high performance allowed the examination of these patients without the use of any special medication to lower the patients' heart rate. All coronary vessels were included for evaluation and all segments could be evaluated. The authors conclude that the Somatom Sensation 64 provides a high diagnostic accuracy in assessing coronary artery stenosis, compared to conventional invasive angiography.

These results were confirmed by the group of Raff et al. from William Beaumont Hospital, Royal Oak, Mich., by comparing the accuracy of the Somatom Sensation Cardiac 64 in detecting and accurately measuring coronary lesions to conventional angiography including Quantitative Coronary Analysis.

Another research team from Klinikum Grosshadern, University of Munich, led by Leber et al., evaluated the accuracy of the Somatom Sensation 64 to detect and differentiate different types of coronary plaques, and to determine plaque burden compared to IVUS. According to the authors, the measurements of plaque and lumen area by CT correlated very well with measurements performed with IVUS.

The Somatom Sensation 64 incorporates Siemens proprietary z-Sharp Technology, which allows two focal points from the anode via precise deflection of the electron beam within the X-ray tube, generating two overlapping beams that pass the scan field. The double readout of the detector produces 64 slice projections down to 0.3 mm slice distance without increasing the radiation dose beyond a 16-slice CT. Further, Siemens' proprietary high-speed, ultra fast ceramic detector enables a virtually simultaneous read-out of two projections for each detector element, resulting in 64-slice acquisition. With z-Sharp Technology the system delivers optimal image quality with a routine isotropic resolution of below 0.4 millimeters, firmly establishing a new benchmark for diagnostic excellence.

With the combination of Speed4D Technology and the world's fastest gantry rotation speed of up to 0.33 seconds, the Somatom Sensation 64 also offers the fastest scan speed, achieving a temporal resolution of up to 83 milliseconds, and thus facilitates scanning of patients even with higher heart rates, virtually freezing the heart's motion. For the first time, this CT performance allows for the evaluation of the most common causes of acute chest pain with a single scan.

De-worming campaign launched among children in northern Sri Lanka

Thousands of children lined up at schools and health centers in northern Sri Lanka on Wednesday to receive de-worming medicine that kills the sometimes deadly parasites and protects against new infection, the International Organization of Migration said. The de-worming project, funded by the Australian government's overseas aid arm AUSAID, targets about 30,000 refugee children in Mannar district, said Qasim Sufi, an IOM official.

"The risks of worms should not be underestimated, with as many as 150,000 children dying worldwide each year from intestinal obstructions and other abdominal complications caused by large adult worms," Sufi said.

The parasites can cause anemia and dysentery, while serious cases can result in malnutrition, stunted growth, delayed puberty, or death. It is not uncommon for children in developing countries to carry up to 1,000 hookworms, roundworms and whipworms - they can pick up hookworms by walking barefoot, and can ingest roundworm eggs by putting dirty fingers in their mouths.

The de-worming campaign will be complemented with projects to promote better heath and hygiene, Sufi said. A single dose of de-worming medication kills all parasites in the recipient's body and protects against possible infection for another year, he said.

Manner is home to thousands of refugees who fled to India during Sri Lanka's 19-year civil war who have returned since a cease-fire was signed in 2002. The International Organization of Migration is involved in the humane management of migration issues around the world.

Medicos identify right Ramzan drug for diabetic Muslims

A transnational study by medicos in India, Pakistan and Bangladesh has identified the right drug that would allow Muslim diabetics to fast during Ramazan without falling ill.

Muslim diabetics, who fast during Ramzan, expose themselves to a greater risk of complications like hypoglycaemia and ketoacidosis.

The study was compiled from a number of research papers by a team of endocrinologists in Srinagar (India), Karachi (Pakistan) and Dhaka (Bangladesh).

It also concluded that although a majority of Muslim patients with Type two diabetes fast during the month of Ramzan, there were no accepted guidelines for the management of the blood sugar anomaly during that period.

The study findings have led the team to identify medicinal formulations of sulphonylureas (first line drugs used in type two diabetes) that could become the 'drug of choice during Ramzan'.

The three medicos who made the study are -- Dr Abdul Zargar, head of the endocrinology department of S K Institute of Medical Sciences, Srinagar, Dr Abdul Basit, head of the Baqai Institute of diabetology and endocrinology in Karachi's Baqai Medical University and Dr Hajera Mahtab, director of clinical services, research and academy at BIRDEM Hospital in Dhaka.

They published their research in the latest issue of the Journal of Indian Medical Association (JIMA). Although Islam exempts sick persons from fasting, a global meet to establish guidelines recently had suggested that patients with stable type two diabetes mellitus under treatment with sulphonylurea could safely fast. The medicos compiled research data to analyse that meal timings during Ramazan lead to alteraction in physical activity, food intake, sugar intake, fluid intake, weight and sleep duration in approximately half of the fasting patients.

Reports on drug intake during Ramadan varied. A large epidemiological survey in 13 countries with sizeable Muslim populations, including India, had earlier reported that 25 per cent patients changed their oral drug doses while fasting.

However, all fasting diabetics showed significantly greater hypoglycaemia (low blood sugar) and ketoacidosis (a condition where body fats are used up and produce poisonous chemicals called ketones) due to change in drug, food and sugar intake patterns, the study said.

During Ramzan, it is difficult to prescribe multiple drug doses since they have to be taken with food, the team said, adding "this rules out the use of multiple dose formulation glipizide and twice-daily dose gliclazide."

A modified release of gliclazide the action of which could be spread over 24 hours has been found to be the best bet for fasting patients, the team said.

A 10-week study of type two diabetics treated with gliclazide MR (modified release) showed significantly reduced blood glucose levels throughout 24 hours, the team said.

During Ramzan, the medicos suggested, the drug should be taken in the evening during the first meal after fast rather than breakfast.

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